104827-57-8

Basic information

• Product Name: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-
• CAS NO: 104827-57-8
• Molecular Formula: C12H11ClN4S
• Molecular Weight: 278.765
• Mol File: 104827-57-8.mol

Chemical Properties

• CAS DataBase Reference: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-(104827-57-8)
• EPA Substance Registry System: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-(104827-57-8)

Safety Data

• Hazardous Substances Data: 104827-57-8(Hazardous Substances Data)

Upstream product

• 73568-26-0 2-chloro-8-methyl-quinoline-3-carbaldehyde 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1418009-65-0 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-(4-methoxyphenyl)thiazole 
• 1418009-68-3 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole 
• 1418009-66-1 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-(2-chlorophenyl)thiazole 
• 1418009-67-2 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-(4-chlorophenyl)thiazole 
• 1418009-64-9 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-p-tolylthiazole 
• 1418009-63-8 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-phenylthiazole 
• 1418009-69-4 2-(2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinyl)-4-(4-nitrophenyl)thiazole 
• 1418921-11-5 3-chloro-4-(2-chloro-8-methylquinolin-3-yl)-1-(4-(4-nitropheny)lthiazol-2-ylamino)azetidin-2-one 
• 1418920-88-3 3-chloro-4-(2-chloro-8-methylquinolin-3-yl)-1-(4-(4-fluoropheny)lthiazol-2-ylamino)azetidin-2-one 
• 1418920-86-1 3-chloro-4-(2-chloro-8-methylquinolin-3-yl)-1-(4-(4-chloropheny)lthiazol-2-ylamino)azetidin-2-one 
• 1418920-61-2 3-chloro-4-(2-chloro-8-methylquinolin-3-yl)-1-(4-(2-chloropheny)lthiazol-2-ylamino)azetidin-2-one 
• 1418920-22-5 3-chloro-4-(2-chloro-8-methylquinolin-3-yl)-1-(4-(4-methoxypheny)lthiazol-2-ylamino)azetidin-2-one 
• 1418919-96-6 3-chloro-4-(2-chloro-8-methylquinolin-3-yl)-1-(4-p-tolylthiazol-2-ylamino)azetidin-2-one 

Relevant articles and documents

Facile synthesis of novel quinoline derivatives as anticancer agents

Convenient and efficient synthesis of novel N-(4-Acetyl-4,5-dihydro-5-(7,8, 9-substituted-tetrazolo[1,5-A]-quinolin-4-yl)-1,3,4-thiadiazol-2-yl)acetamides 4a-j and their in vitro anticancer activity against two cell lines viz., human breast cancer cell line MCF7 and human cervix cancer cell line HeLa were carried out. GI50, LC50, TGI values were evaluated. Two of the compounds 4e and 4i with halogen substituent at 7th position of the target molecules have shown potent activity against human cervix cancer cell line HeLa. DNA cleavage studies revealed that most of these compounds show partial cleavage and few of them show complete cleavage of DNA.

Synthesis, characterization and antimicrobial screening of some quinoline based dihydropyridine and 2-oxo-azetidine derivatives

2-Chloro-8-methylquinoline-3-carbaldehyde 1 on treatment with 2-cyanoacetohydrazide and thiosemicarbazide yields schiff bases N′-((2-chloroquinolin-3-yl)methylene)-2-cyanoacetohydrazide 2 and 2-((2-chloro-8-methylquinolin-3-yl)methylene)hydrazinecarbothioamide 4, respectively. Compounds 2 and 4 have been used to obtain a series of titled compounds containing azetidinone, thiazole and 2-pyridone scaffolds incorporating quinoline nucleus. The newly synthesized compounds 3a-j and 6a-g have been screened for their antibacterial and antifungal activities and their chemical structures have been elucidated by spectral data.

3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: Synthesis, characterization and anti-microbial activity

A new series of thiadiazoles and intermediate thiosemicarbazones were synthesized from the chloroquinone molecule, with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. The chemical structures of the compound were elucidated by elemental analysis, FTIR, 1H and 13C NMR and ESI-MS spectral data. In vitro anti-microbial activity was performed against Staphylococcusaureus, Streptococcuspyogenes, Salmonellatyphimurium, and Escherichiacoli. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibit area/μg of the compounds and the standard "amoxicillin". The selected compounds were tested for cytotoxic results using MTT assay H9c2 cardiac myoblasts cell line and the results showed that all the compounds offered remarkable >80% viability to a concentration of 200 μg/mL.