104827-61-4

Basic information

• Product Name: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-N-cyclohexyl-
• CAS NO: 104827-61-4
• Molecular Formula: C18H21ClN4S
• Molecular Weight: 360.911
• Mol File: 104827-61-4.mol

Chemical Properties

• CAS DataBase Reference: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-N-cyclohexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-N-cyclohexyl-(104827-61-4)
• EPA Substance Registry System: Hydrazinecarbothioamide, 2-[(2-chloro-8-methyl-3-quinolinyl)methylene]-N-cyclohexyl-(104827-61-4)

Safety Data

• Hazardous Substances Data: 104827-61-4(Hazardous Substances Data)

Upstream product

• 73568-26-0 2-chloro-8-methyl-quinoline-3-carbaldehyde 
• 21198-18-5 4-cyclohexyl-thiosemicarbazide 
• 108-91-8 cyclohexylamine 
• 112864-51-4 cyclohexylthiocarbamoylsulfanyl-acetic acid 

Downstream Products

• 1313027-79-0 N-(4-acetyl-5-(2-chloro-8-methylquinolin-3-yl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-cyclohexylacetamide 

Relevant articles and documents

3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: Synthesis, characterization and anti-microbial activity

A new series of thiadiazoles and intermediate thiosemicarbazones were synthesized from the chloroquinone molecule, with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection. The chemical structures of the compound were elucidated by elemental analysis, FTIR, 1H and 13C NMR and ESI-MS spectral data. In vitro anti-microbial activity was performed against Staphylococcusaureus, Streptococcuspyogenes, Salmonellatyphimurium, and Escherichiacoli. The MIC was detected using the double dilution method. The results were compared by calculating percent inhibit area/μg of the compounds and the standard "amoxicillin". The selected compounds were tested for cytotoxic results using MTT assay H9c2 cardiac myoblasts cell line and the results showed that all the compounds offered remarkable >80% viability to a concentration of 200 μg/mL.