1048337-83-2Relevant academic research and scientific papers
Enantiomerically pure cyclopropylamines from cyclopropylboronic esters
Pietruszka, Joerg,Solduga, Gemma
supporting information; experimental part, p. 5998 - 6008 (2010/03/01)
Cyclopropylamines are versatile intermediates and products both in organic synthesis in general and for active substances in particular. Although the synthesis of the corresponding enantiomerically pure cyclopropylboronic esters had been established previously, the C-B to C-N transformation was elusive. A detailed, study directed towards the synthesis of several enantiomerically pure cyclopropylamines is disclosed; tranylcypromine [(1S, 2R)-36] and the known belactosin A intermediate 43 were both obtained by use of trifluoroborates as key intermediates.
