104834-45-9Relevant academic research and scientific papers
Ring Syntheses of the Four N-Methylprotoporphyrin Isomers and of Related N-Methyl and N,N'-Dimethylporphyrins
Pandey, Ravindra K.,Jackson, Anthony H.,Smith, Kevin M.
, p. 1211 - 1220 (2007/10/02)
Total syntheses of the four isomeric N-methylprotoporphyrin IX dimethyl esters have been achieved by the MacDonald and tripyrrene/a,c-biladiene routes using appropriate N-methylpyrroles and N-methyldipyrromethanes as intermediates.The syntheses of related N-methyl and N,N'-dimethylporphyrins have also been achieved by the MacDonald route.
Total Syntheses of Derivatives of Protoporphyrin IX Regioselectively Labeled with Carbon-13 in the Methyls
Smith, Kevin M.,Fujinari, Eugene M.,Pandey, Ravindra K.,Tabba, Hani D.
, p. 4667 - 4676 (2007/10/02)
Total syntheses, from monopyrroles via tripyrrenes and a,c-biladienes, of the four isomers 2-5 of protoporphyrin IX dimethyl ester in which the 1-, 3-, 5-, and 8-methyl groups are individually and regioselectively enriched with carbon-13 are described.The source of labeled carbon was 90percent carbon-13-enriched paraformaldehyde, and methyls were inserted at the monopyrrole stage by reductive C-alkylation.The carbon-13-labeled porphyrins, as the corresponding hemes, are of interest as probes in carbon-13 NMR spectroscopic studies of reconstituted heme proteins.
