1048350-75-9Relevant academic research and scientific papers
Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
Galley, Guido,Beurier, Angélica,Décoret, Guillaume,Goergler, Annick,Hutter, Roman,Mohr, Susanne,P?hler, Axel,Schmid, Philipp,Türck, Dietrich,Unger, Robert,Zbinden, Katrin Groebke,Hoener, Marius C.,Norcross, Roger D.
, p. 192 - 197 (2016/03/01)
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound 1, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as 12 (RO5166017), 18 (RO5256390), 36 (RO5203648), and 48 (RO5263397). These compounds exhibit drug-like physicochemical properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction.
Pharmaceutical combination
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Page/Page column 14, (2015/10/05)
The present invention relates to a pharmaceutical combination for the treatment of schizophrenia and acute manic episodes associated with bipolar disorders, which comprises a compound which is active on a trace amine-associated receptor 1 (TAAR1 agonist)
PHARMACEUTICAL COMBINATION
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, (2012/02/06)
The present invention relates to a pharmaceutical combination for the treatment of schizophrenia and acute manic episodes associated with bipolar disorders, which comprises a compound which is active on a trace amine-associated receptor 1 (TAAR1 agonist)
