1048367-66-3Relevant academic research and scientific papers
Discovery of benzothiazole derivatives as efficacious and enterocyte-specific MTP inhibitors
Vu, Chi B.,Milne, Jill C.,Carney, David P.,Song, Jeffrey,Choy, Wendy,Lambert, Philip D.,Gagne, David J.,Hirsch, Michael,Cote, Angela,Davis, Meghan,Lainez, Elden,Meade, Nekeya,Normington, Karl,Jirousek, Michael R.,Perni, Robert B.
scheme or table, p. 1416 - 1420 (2009/11/30)
A series of triamide derivatives bearing a benzothiazole core is shown to be potent microsomal triglyceride transfer protein (MTP) inhibitors. In order to minimize liver toxicity, these compounds have been optimized to have activity only in the enterocyte
