1048388-22-2Relevant academic research and scientific papers
Piperazinyl pyrimidine derivatives as potent γ-secretase modulators
Rivkin, Alexey,Ahearn, Sean P.,Chichetti, Stephanie M.,Kim, Yoona R.,Li, Chaomin,Rosenau, Andrew,Kattar, Sam D.,Jung, Joon,Shah, Sanjiv,Hughes, Bethany L.,Crispino, Jamie L.,Middleton, Richard E.,Szewczak, Alexander A.,Munoz, Benito,Shearman, Mark S.
scheme or table, p. 1269 - 1271 (2010/06/15)
The development of a novel series of piperazinyl pyrimidines as γ-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a screening hit provided a series of potent γ-secretase modulators with >
PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS
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Page/Page column 34, (2008/12/08)
Compounds of formula (I) selectively inhibitproduction of Aβ(1-42) and hence find use in treatment of Alzheimer's disease and other conditions associated with deposition ofA(β) in the brain.
