104855-18-7Relevant academic research and scientific papers
Phenalenones from a marine-derived fungus Penicillium sp.
Park, Sung Chul,Julianti, Elin,Ahn, Sungjin,Kim, Donghwa,Lee, Sang Kook,Noh, Minsoo,Oh, Dong-Chan,Oh, Ki-Bong,Shin, Jongheon
, (2019)
Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.
METABOLITES PRODUCED BY THE SCLERODERRIS CANKER FUNGUS, GREMMENIELLA ABIETINA. PART 4. BIOSYNTHETIC STUDIES
Ayer, William A.,Pedras, M. Soledade,Ward, Dale E.
, p. 760 - 764 (2007/10/02)
The biosynthetic origin of the carbon atoms of the most highly oxidized, polyketide derived, ring (carbon 1-3) of the Gremmeniella abietina metabolites sclerodione (3), scleroderolide (4), sclerodin (5), and Scleroderris green (6) has been studied.It is shown that both C-1 and C-3 of 3 and 4 are derived from C-1 of acetate, and that C-2 of scleroderolide (4) is derived fom C-2 acetate while C-3 is derived from C-1 of acetate.As expected, C-1 and C-3 of Scleroderris green (6) originate from the carboxyl carbon of acetate, while C-2 originates from the methyl carbon of acetate.Complete 13C and 1H nuclear magnetic resonance spectra of these metabolites are reported.It has also been shown that ent-atrovenetin (ent-7a) is a metabolite of G. abietina.
METABOLITES PRODUCED BY THE SCLERODERRIS CANKER FUNGUS, GREMMENIELLA ABIETINA. PART 2. THE STRUCTURE OF SCLERODEROLIDE
Ayer, William A.,Hoyano, Yumiko,Pedras, M. Soledade,Clardy, Jon,Arnold, Edward
, p. 748 - 753 (2007/10/02)
Scleroderolide, a yellow pigment produced by the Scleroderris canker fungus Gremmeniella abietina (Lagerb.) Morelet, is shown to possess structure 1.The structure was determined by an X-ray crystallographic study of the racemic monoacetate 1a.The crystal
Metabolites produced by the Scleroderris canker fungus, Gremmeniella abietina. Part 1
Ayer, William A.,Hoyano, Yumiko,Pedras, M. Soledade,van Altena, Ian
, p. 1585 - 1589 (2007/10/02)
The metabolites produced in liquid culture by the Ascomycetous fungus Gremmeniella abietina (Lagerb.).Morelet, the causative agent of Scleroderris canker in pines, have been investigated.The major metabolite, which we have named sclerodin, is (-)-4,7-dihydroxy-2,3,3,9-tetramethyl-2,3-dihydronaphthofuran-5,6-dicarboxylic anhydride (1), the enantiomer of the so-called "naphthalic anhydride from atrovenetin".Several highly colored compounds, including the enantiomer of atrovenetinone (3), the blue compound 6, the red acenaphthenequinone derivative 8 (sclerodione), and the yellow 8-hydroxysclerodione (8) has been transformed into sclerodin (1).
