10486-46-1

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-2,3,5-TRIMETHYL-PHENOL is used as a reactant for the synthesis of SUN N8075, a dual sodium and calcium channel blocker with antioxidant activity. This application is significant because it contributes to the development of medications that can potentially treat conditions related to abnormal ion channel activity and oxidative stress.

Upstream product

• 697-82-5 2,3,5-trimethylphenol 
• 497-19-8 sodium carbonate 
• 121-57-3 4-aminobenzene sulfonic acid 
• 92892-04-1 2,3,5-trimethyl-4-nitrophenol 
• 1778-66-1 2,3,6-Trimethyl-4-(4-nitro-phenylazo)-phenol 

Downstream Products

• 224450-46-8 tert-butyl 4-hydroxy-2,3,6-trimethylphenylcarbamate 
• 142874-32-6 [4-(acetylamino)-2,3,5-trimethylphenyl] acetate 
• 99075-42-0 N-(4-hydroxy-2,3,6-trimethylphenyl)-formamide 
• 301523-78-4 [4-(3-{4-[4-(4-fluoro-benzyl)-phenyl]-piperazin-1-yl}-2-hydroxy-propoxy)-2,3,6-trimethyl-phenyl]-carbamic acid tert-butyl ester 
• 224450-44-6 (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl)phenyl]-1-piperazinyl}-2-propanol 
• 224449-73-4 (2S)-1-[(4-tert-butoxycarbonylamino-2,3,5-trimethyl)-phenoxy]-2,3-epoxypropane 
• 36592-62-8 4-acetoxy-2,3,5-trimethylphenol 

Relevant academic research and scientific papers

Competitive Pseudopericyclic [3,3]- and [3,5]-Sigmatropic Rearrangements of Trichloroacetimidates

The Woodward-Hoffmann rules predict whether concerted pericyclic reactions are allowed or forbidden based on the number of electrons involved and whether the cyclic orbital overlap involves suprafacial or antarafacial orbital overlap. Pseudopericyclic reactions constitute a third class of reactions in which orthogonal orbitals make them orbital symmetry allowed, regardless of the number of electrons involved in the reaction. Based on the recent report of eight-centered ester rearrangements, it is predicted that the isoelectronic eight-centered rearrangements of imidates would also be allowed. We now report that these rearrangements occur, and indeed, an eight-centered rearrangement is slightly favored in at least one case over the well-known six-centered Overman rearrangements, in a trichloroacetimidoylcyclohexadienone, a molecular system where both rearrangements are possible.

Aminocoumaran derivatives, their production and use

A novel aminocoumaran derivatives of the general formula (I): STR1 wherein R1 and R2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R3 R4 and R5 are an optionally acylated hydroxyl optionally substituted amino group, alkoxy group or aliphatic group, or two of R3, R4 and R5 may be linked together to form a carbocyclic group; R6 and R7 are an aliphatic group and at least one of them has a methylene group at the α-position; R8 and R9 are a hydrogen atom or an aliphatic group or aromatic group, or a salt thereof is useful for medicines for preventing and treating various diseases such as arterial schleosis, hepatopathy, cerebrovascular diseases and the like.

Process for dyeing keratinous fibers combining isatin or its derivatives with a tri-, tetra- or pentasubstituted aniline or with a bisphenylalkylenediamine, and dyeing agents

The invention relates to a process for dyeing keratinous fibres, comprising the simultaneous or sequential application of a component (A) containing at least one compound of formula (I): STR1 in which: R1 denotes hydrogen, alkyl, acetyl, benzoyl, phenyl or C1 -C4 carboxyalkyl, R2 and R3 denote hydrogen, alkyl, alkoxy, hydroxyalkyl, amino, halogen, nitro, alkylphenyl, phenyl, alkylamino or hydroxyalkylamino, and a component (B) containing at least (i) a compound of formula (II): STR2 in which: Y denotes OH or NR8 R9, R8 and R9, which are identical or different, denote hydrogen, aminoethyl, hydroxyethyl or C1 -C4 alkyl, R4 to R7 independently of each other denote a hydrogen atom, a C1 -C4 alkyl, a chlorine, a C1 -C4 alkoxy, an acetylamino, an aryloxy, not more than two of the groups R4 to R7 denote a hydrogen atom, excluding 2,5-dimethoxy-1,4-diaminobenzene, and the cosmetically acceptable salts, or (ii) a bisphenylalkylenediamine. It also relates to the dyeing agents for implementing it.