104863-49-2

Basic information

• Product Name: 2-Thiazolemethanol, alpha-methyl-, (alphaS)- (9CI)
• Synonyms: 2-Thiazolemethanol, alpha-methyl-, (alphaS)- (9CI)
• CAS NO: 104863-49-2
• Molecular Formula: C₅H₇NOS
• Molecular Weight: 129.18018
• Product Categories: ACETYLGROUP
• Mol File: 104863-49-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Thiazolemethanol, alpha-methyl-, (alphaS)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolemethanol, alpha-methyl-, (alphaS)- (9CI)(104863-49-2)
• EPA Substance Registry System: 2-Thiazolemethanol, alpha-methyl-, (alphaS)- (9CI)(104863-49-2)

Safety Data

• Hazardous Substances Data: 104863-49-2(Hazardous Substances Data)

Upstream product

• 24295-03-2 2-Acetylthiazole 
• 40982-30-7 (±)-1-(thiazol-2-yl)ethanol 
• 371-27-7 2,2,2-trifluoroethylbutyrate 
• 117-34-0 2,2-diphenylacetic acid 

Relevant articles and documents

Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones

(formula presented) In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 2000:1 are employed.

General asymmetric hydrogenation of hetero-aromatic ketones

(matrix presented) Het = hetero-aromatic ring (R,R)-Ru cat = trans-RuCl2[(R)-xylbinap][(R)-daipen] trans-RuCl2[(R)-xylbinap][(R)-daipen] or the S,S complex acts as an efficient catalyst for asymmetric hydrogenation of hetero-aromatic ketones. The hydrogenation proceeds with a substrate-to-catalyst molar ratio of 1000-40000 to give chiral alcohols in high ee and high yield. The enantioselectivity appears to be little affected by the properties of the hetero-aromatic ring. This method allows for asymmetric synthesis of duloxetine, an inhibitor of serotonin and norepinephrine uptake carriers.

Kinetic resolution of racemic 1-heteroarylalkanols by asymmetric esterification using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst

A variety of optically active 1-heteroarylalkanols and their esters, which include heteroaromatic moieties, such as 2-furyl, 2-thienyl, 3-thienyl, 2-thiazoyl, 2-benzothiazoyl, and 2-benzoxazoyl groups, are efficiently produced by a novel asymmetric esterification. The transition states that form the desired (R)- esters from the (R)-1-heteroarylalkanols are determined by DFT calculations, and the structural features of these transition states are systematically discussed.