1048654-48-3Relevant academic research and scientific papers
Design and scalable synthesis of new chiral selectors. Part 1: Synthesis and characterization of a new constrained cyclopeptide from unnatural bulky amino acids
Ferron, Laurent,Guillen, Frederic,Coste, Servane,Coquerel, Gerard,Cardinael, Pascal,Schwartz, Joel,Paris, Jean-Marc,Plaquevent, Jean-Christophe
, p. 6036 - 6044 (2011/09/12)
We describe the conception, synthesis, and characterization of a novel cyclopeptide designed for chiral recognition. The asymmetric units are built from an unnatural amino acid in the series of α-aryl-α-methyl glycine. Modifications of standard methods of peptide synthesis are described in order to improve yields and purities when applied to hindered amino acids. First set of experiments about host-guest ability of the obtained cyclopeptide is disclosed.
