1048660-06-5 Usage
Chemical class
Indole derivatives
Structure
Benzyl ester of 4-methoxy-1H-indole-2-carboxylic acid
Usage
Organic synthesis and medicinal chemistry
Pharmacological activities
Anti-inflammatory, antioxidant, and neuroprotective properties
Potential use
Drug candidate for the treatment of various diseases
Application
Intermediate in the synthesis of pharmaceuticals and other organic compounds
Check Digit Verification of cas no
The CAS Registry Mumber 1048660-06-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,8,6,6 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1048660-06:
(9*1)+(8*0)+(7*4)+(6*8)+(5*6)+(4*6)+(3*0)+(2*0)+(1*6)=145
145 % 10 = 5
So 1048660-06-5 is a valid CAS Registry Number.
1048660-06-5Relevant academic research and scientific papers
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
Oslund, Rob C.,Cermak, Nathan,Gelb, Michael H.
supporting information; experimental part, p. 4708 - 4714 (2009/06/06)
We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6,7-benzoindoles, and indolizines derived from LY315920, a well-known indole-based sPLA2 inhibitor. Using the human group X sPLA2 crystal structure, we prepared a highly potent and selective indole-based inhibitor of this enzyme. Also, we report human and mouse group IIA and IIE specific inhibitors and a substituted 6,7-benzoindole that inhibits nearly all human and mouse sPLA 2s in the low nanomolar range.
