1048685-50-2

Basic information

• Product Name: C₂₁H₂₄N₂O₄
• Synonyms: C₂₁H₂₄N₂O₄
• CAS NO: 1048685-50-2
• Molecular Weight: 368.433
• Mol File: 1048685-50-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄N₂O₄(1048685-50-2)
• EPA Substance Registry System: C₂₁H₂₄N₂O₄(1048685-50-2)

Safety Data

• Hazardous Substances Data: 1048685-50-2(Hazardous Substances Data)

Upstream product

• 380607-13-6 5,6-dimethoxy-1-methyl-1H-indole-2-carboxylic acid 
• 104-63-2 N-Benzylethanolamine 
• 74-88-4 methyl iodide 

Downstream Products

• 1048685-55-7 C₂₁H₂₀N₂O₃ 

Relevant articles and documents

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted β-carbolin-1-ones

A series of β-carbolin-2-ones and 3,10-dihydro-2H-azepino[3,4-b]indol- 1-ones have been designed, synthesized, and evaluated as RET protein kinase inhibitors on the basis of their structural similarity with the prototype indolin-2-one RPI-1. Some β-carbolin-2-ones (structure 2) showed an ability to inhibit RET enzymatic activity in vitro and proliferation of RETC634R oncogene-transformed NIH3T3 cells comparable to that of the reference compound. The docking analysis of the interaction of these compounds with the crystallographic structure of RET tyrosine kinase domain suggested a new binding interaction scheme different from the one proposed during their design. The rigid structure of the compounds of this series represents a new scaffold with potential advantages in the design of RET protein kinase inhibitors.