1048692-45-0

Upstream product

• 1048692-42-7 (S)-tert-butyl (1-(dibenzylamino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 

Downstream Products

• 1048692-48-3 (S)-N¹,N¹-dibenzyl-3-methylbutane-1,2-diamine 
• 1341212-03-0 (S)-N,N-dibenzyl-4-((S)-1-(diphenylphosphino)-3-methylbutan-2-ylamino)-2-isopropyl-4-thioxobutanamide 
• 1341212-18-7 C₂₀H₂₂N₂OS 

Relevant academic research and scientific papers

Ag2CO3/CA-AA-amidphos multifunctional catalysis in the enantioselective 1,3-dipolar cycloaddition of azomethine ylides

The new Ag2CO3/CA-AA-amidphos complexes have been demonstrated as highly efficient multifunctional catalysts in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides. Under optimal conditions, highly functionalized endo-4 pyrrolidines were obtained with excellent yields (up to 99% yield) and enantioselectivities (up to 96% ee).

Enantioselective Morita-Baylis-Hillman reaction promoted by l-threonine-derived phosphine-thiourea catalysts

A series of bifunctional phosphine-thiourea organic catalysts based on natural amino acid scaffolds were designed and prepared. l-Threonine-derived bifunctional phosphine catalysts were found to be very efficient in promoting asymmetric Morita-Baylis-Hillman (MBH) reaction of acrylates with aromatic aldehydes, affording the desired MBH adducts with up to 90% ee. To gain mechanistic insights into the reaction, the effects of adding various additives on the MBH reaction were investigated. We propose that the hydrogen bonding interactions between the thiourea moiety of the catalyst and the enolate intermediate are crucial for the stereochemical outcome of the reaction. The method described in this report may provide a practical solution to the enantioselective MBH reaction of simple acrylates.

Novel bifunctional chiral urea and thiourea derivatives as organocatalysts: Enantioselective nitro-Michael reaction of malonates and diketones

A modular synthesis of novel bifunctional urea and thiourea organocatalysts derived from cheap, easily accessible natural and non-natural amino acids was reported. The generality of the synthesis was demonstrated in the preparation of catalysts 4a-i in th