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N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(2S)-2-(dimethylamino)-3-methylbutyl]-thiourea, commonly referred to as TBTU, is a specialized chemical compound that functions as a reagent in the realm of organic chemistry. It is a derivative of thiourea, characterized by the presence of sulfur, and is enriched with fluorine and methyl groups. TBTU is recognized for its role as a coupling reagent in peptide synthesis, a process integral to the formation of proteins from amino acids. As a mild and efficient reagent for creating peptide bonds, TBTU is highly valued in biochemistry and pharmaceutical research, despite the need for careful handling due to its potential toxicity and irritancy.

1048692-60-9

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1048692-60-9 Usage

Uses

Used in Pharmaceutical Research:
TBTU is employed as a coupling reagent in the synthesis of peptides, which are essential for the development of new drugs and understanding protein functions. Its efficiency in peptide bond formation aids researchers in creating complex protein structures for therapeutic applications.
Used in Biochemical Studies:
In the field of biochemistry, TBTU serves as a valuable tool for studying the mechanisms of protein synthesis and the properties of peptides. Its mild reactivity allows for the exploration of peptide interactions and folding without causing unwanted side reactions.
Used in Organic Chemistry:
TBTU is utilized in various organic chemistry applications, particularly in the synthesis of complex organic molecules that incorporate peptide bonds. Its role as a coupling reagent is crucial for the successful formation of these molecules, contributing to the advancement of organic synthesis techniques.
Used in Drug Development:
TBTU plays a significant role in the development of pharmaceuticals, as it facilitates the synthesis of peptides that can be used as drug candidates. Its contribution to the creation of bioactive peptides makes it an important component in the drug discovery process.
Used in Biomedical Research:
In biomedical research, TBTU is applied to study the structure and function of proteins, as well as their interactions with other biomolecules. Its use in peptide synthesis allows researchers to investigate the roles of specific protein sequences in biological processes and diseases.
Overall, TBTU is a versatile reagent with applications across various scientific disciplines, particularly in the synthesis and study of peptides, which are fundamental to the development of new pharmaceuticals and the understanding of biological systems.

Check Digit Verification of cas no

The CAS Registry Mumber 1048692-60-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,8,6,9 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1048692-60:
(9*1)+(8*0)+(7*4)+(6*8)+(5*6)+(4*9)+(3*2)+(2*6)+(1*0)=169
169 % 10 = 9
So 1048692-60-9 is a valid CAS Registry Number.

1048692-60-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S)-1-(dimethylamino)-2-methylpropyl]thiourea

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:1048692-60-9 SDS

1048692-60-9Downstream Products

1048692-60-9Relevant academic research and scientific papers

Novel bifunctional chiral urea and thiourea derivatives as organocatalysts: Enantioselective nitro-Michael reaction of malonates and diketones

Andres, Jose M.,Manzano, Ruben,Pedrosa, Rafae

supporting information; experimental part, p. 5116 - 5119 (2009/05/27)

A modular synthesis of novel bifunctional urea and thiourea organocatalysts derived from cheap, easily accessible natural and non-natural amino acids was reported. The generality of the synthesis was demonstrated in the preparation of catalysts 4a-i in th

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