104882-72-6Relevant academic research and scientific papers
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: Synthesis and biological evaluation of dihydropyridin-2-imines
Kawanaka, Yasufumi,Kobayashi, Kaoru,Kusuda, Shinya,Tatsumi, Tadashi,Murota, Masanori,Nishiyama, Toshihiko,Hisaichi, Katsuya,Fujii, Atsuko,Hirai, Keisuke,Naka, Masao,Komeno, Masaharu,Nakai, Hisao,Toda, Masaaki
, p. 2291 - 2294 (2002)
Dihydropyridin-2-imines were synthesized and biologically evaluated both in vitro and in vivo using a nitric oxide inhibition assay. Compounds 1, 4, 5 and 7-11 exhibited potent activity in the inducible nitric oxide (iNOS) inhibition assay. Of these 5, 6,
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines
Kawanaka, Yasufumi,Kobayashi, Kaoru,Kusuda, Shinya,Tatsumi, Tadashi,Murota, Masayuki,Nishiyama, Toshihiko,Hisaichi, Katsuya,Fujii, Atsuko,Hirai, Keisuke,Nishizaki, Minoru,Naka, Masao,Komeno, Masaharu,Nakai, Hisao,Toda, Masaaki
, p. 689 - 702 (2007/10/03)
The process of discovery and biological evaluation of α,β-unsaturated cyclic amidines, as selective inhibitors of inducible nitric oxide synthase (iNOS), is reported. Dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines were synthesized a
Olivanic Acid Analogues. Part 2. Total Synthesis of Some C(6)-Substituted 7-Oxo-1-azabicyclohept-2-ene-2-carboxylates
Bateson, John H.,Quinn, Alison M.,Smale, Terence C.,Southgate, Robert
, p. 2219 - 2234 (2007/10/02)
A number of 6-substituted 7-oxo-1-azabicyclohept-2-ene-2-carboxylates related to the olivanic acids were prepared from the phosphorane (32).Generation of the anion α to the azetidin-2-one carbonyl group, followed by reaction with electrophiles and intramolecular cyclisation using the Wittig procedure gave the bicyclic products; in all cases the thermodynamically favoured trans-stereochemisty about the azetidinone ring predominated.In contrast, some less readily available cis-substituted analogues were obtained from the cyclohexa-1,4-diene derived phosphorane (61).The synthetic utility of a masked acetonyl ester group for preparing the free acids of these azabicycloheptene ring systems is described.
