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104890-73-5

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104890-73-5 Usage

General Description

1-(4-chlorophenyl)-3-(2,6-dichlorophenyl)prop-2-en-1-one, also known as curcumin, is a chemical compound with a bright yellow color and a characteristic taste. It is found naturally in the rhizome of the turmeric plant and has been used for centuries in traditional medicine. Curcumin has been the subject of numerous studies for its potential health benefits, including anti-inflammatory, antioxidant, and anticancer properties. It is also being investigated for its potential neuroprotective and antidepressant effects. In addition, curcumin is used as a food coloring and flavoring agent and has applications in the pharmaceutical and cosmetic industries.

Check Digit Verification of cas no

The CAS Registry Mumber 104890-73-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,8,9 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 104890-73:
(8*1)+(7*0)+(6*4)+(5*8)+(4*9)+(3*0)+(2*7)+(1*3)=125
125 % 10 = 5
So 104890-73-5 is a valid CAS Registry Number.

104890-73-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-chlorophenyl)-3-(2,6-dichlorophenyl)prop-2-en-1-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:104890-73-5 SDS

104890-73-5Relevant articles and documents

Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion

Yu, Wenquan,Goddard, Cally,Clearfield, Elizabeth,Mills, Courtney,Xiao, Tong,Guo, Haitao,Morrey, John D.,Motter, Neil E.,Zhao, Kang,Block, Timothy M.,Cuconati, Andrea,Xu, Xiaodong

supporting information; experimental part, p. 5660 - 5670 (2011/10/08)

The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals play an important role in suppressing HBV-specific immune response and are only mildly affected by the current small molecule therapies. Thus, a therapy that specifically reduces HBsAg serum levels could be used in combination therapy with nucleos(t)ide drugs or permit therapeutic vaccination for the treatment of HBV infection. Herein, we report the design, synthesis, and evaluation of novel triazolo-pyrimidine inhibitors (1, 3, and 4) of HBsAg cellular secretion, with activity against drug-resistant HBV variants. Extensive SAR led to substantial improvements in the EC50 of the parent compound, 5 (HBF-0259), with the best being 3c, with EC50 = 1.4 ± 0.4 μM, SI ≥ 36. The lead candidates, both 1a (PBHBV-001) and 3c (PBHBV-2-15), were well-tolerated in both normal and HBV-transgenic mice and exhibited acceptable pharmacokinetics and bioavailability in Sprague-Dawley rats.

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