1048974-13-5Relevant academic research and scientific papers
Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases
Chen, Ning,Buerli, Roland W.,Neira, Susana,Hungate, Randall,Zhang, Dawei,Yu, Violeta,Nguyen, Yen,Tudor, Yanyan,Plant, Matthew,Flynn, Shaun,Meagher, Kristin L.,Lee, Matthew R.,Zhang, Xuxia,Itano, Andrea,Schrag, Michael,Xu, Yang,Ng, Gordon Y.,Hu, Essa
scheme or table, p. 4137 - 4141 (2009/05/26)
A potent and selective c-Kit inhibitor 20 was identified through a structure-activity relationship study. In an in vivo mouse model of mast cell activation, 20 blocked the SCF-induced histamine release with an EC50 of 26 nM.
