1048987-98-9Relevant academic research and scientific papers
Reactions of electron-rich indoles with triflic anhydride
Yepuri, Nageshwar R.,Haritakul, Rachada,Keller, Paul A.,Skelton, Brian W.,White, Allan H.
experimental part, p. 2501 - 2504 (2009/09/05)
The reaction of electron-rich 3-aryl-substituted 4,6-dimethoxyindoles in the presence of base with triflic anhydride results in biaryl coupling, producing both 2,2′- and 2,7′-biindoles. Further, if acetone is present, the corresponding vinyl triflate is f
Oxidative coupling of indoles using thallium(III) trifluoroacetate
Keller, Paul A.,Yepuri, Nageshwar R.,Kelso, Michael J.,Mariani, Michael,Skelton, Brian W.,White, Allan H.
, p. 7787 - 7795 (2008/12/21)
The oxidative coupling of polysubstituted electron-rich indoles mediated by thallium trifluoroacetate was found to be a facile, clean, and high yielding reaction. Indolic coupling sites were determined by the nature of the substituents present, with dimerisation at the indole 2-position being the dominant outcome. Indoles bearing two potential reaction sites with similar reactivity were additionally found to undergo heterocoupling.
