1048993-34-5Relevant academic research and scientific papers
Synthesis of spiroacetals using functionalised titanium carbenoids
Main, Calver A.,Rahman, Shahzad S.,Hartley, Richard C.
, p. 4771 - 4774 (2008)
Alkylidenation of lactones with functionalised titanium carbenoid reagents (Schrock carbenes) followed by acid-induced cyclisation of the resulting enol ethers constitutes a new method for the preparation of [4.4], [4.5] and [5.5] spiroacetals (1,6-dioxaspiro[4.4]nonanes, 1,6-dioxaspiro[4.5]decanes and 1,7-dioxaspiro[5.5]undecanes, respectively, sometimes termed 5,5-, 5,6- and 6,6-spiroketals). The titanium carbenoids are easily generated from readily available thioacetals.
