1049093-43-7Relevant articles and documents
ANDROGEN RECEPTOR LIGANDS
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Paragraph 00208; 00212, (2017/07/31)
Described are compounds that inhibit androgen receptor action, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.
Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase
Vandyck, Koen,Cummings, Maxwell D.,Nyanguile, Origène,Boutton, Carlo W.,Vendeville, Sandrine,McGowan, David,Devogelaere, Benoit,Amssoms, Katie,Last, Stefaan,Rombauts, Klara,Tahri, Abdellah,Lory, Pedro,Hu, Lili,Beauchamp, Derek A.,Simmen, Kenny,Raboisson, Pierre
supporting information; experimental part, p. 4099 - 4102 (2010/02/28)
HCV NS5B polymerase, an essential and virus-specific enzyme, is an important target for drug discovery. Using structure-based design, we optimized a 1,5-benzodiazepine NS5B polymerase inhibitor chemotype into a new sulfone-containing scaffold. The design
1,1-DIOXO-1-THIA-5,10-DIAZADIBENZOCYCLOHEPTENES USEFUL AS HEPATITIS C VIRUS INHIBITORS
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, (2008/12/08)
Inhibitors of HCV replication of formula (I) the stereoisomers, prodrugs, tautomers, racemics, salts, hydrates or solvates thereof wherein R1a; R1b R2; R3; R4a and R4b have the meaning defi