1049098-72-7Relevant academic research and scientific papers
Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors
Wiener, Danielle K.,Lee-Dutra, Alice,Bembenek, Scott,Nguyen, Steven,Thurmond, Robin L.,Sun, Siquan,Karlsson, Lars,Grice, Cheryl A.,Jones, Todd K.,Edwards, James P.
scheme or table, p. 2379 - 2382 (2010/07/14)
A series of tetrahydropyrido-pyrazole cathepsin S (CatS) inhibitors with thioether acetamide functional groups were prepared with the goal of improving upon the cellular activity of amidoethylthioethers. This Letter describes altered amide connectivity, in conjunction with changes to other binding elements, resulting in improved potency, as well as increased knowledge of the relationship between this chemotype and human CatS activity.
TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S
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Page/Page column 106, (2009/04/24)
Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by ca
