104961-58-2Relevant articles and documents
Synthesis of Novel 1-Phenyl-1H-indole-2-carboxylic Acids. II. Preparation of 3-Dialkylamino, 3-Alkylthio, 3-Alkylsulfinyl, and 3-Alkylsulfonyl Derivatives
Unangst, Paul C.,Connor, David T.,Stabler, S. Russell
, p. 817 - 820 (2007/10/02)
The synthesis of novel indole-2-carboxylic acids with amino- and sulfur-containing substituents in the indole 3-position is described.An Ullmann reaction with bromobenzene converted 1H-indoles with 3-(acetylamino)- and 3-(diethylamino)-substituents into 1-phenyl-1H-indoles.Reaction of 3-unsubstituted indoles with thionyl chloride provided indole 3-sulfinyl chlorides, which reacted with alkyl and aryl Grignard reagents to form the corresponding sulfoxides.The indole sulfoxides thus obtained were reduced to sulfides or oxidized to sulfones.
Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
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, (2008/06/13)
Novel acidic indole compounds having use as antiallergic agents, methods of synthesis, compositions, and uses are claimed.
