1049681-98-2Relevant academic research and scientific papers
Synthesis of novel 5,7-disubstituted 8-hydroxyquinolines
Himmi, Banacer,Joly, Jean-Pierre,Hlimi, Fouzia,Soufiaoui, Mohamed,Kitane, Said,Bahloul, Abdelmejid,Eddaif, Abdelhamid,Sebban, Abdelfatah
, p. 1023 - 1026 (2008)
(Chemical Equation Presented) Seven new 5,7-disubstituted oxine derivatives have been synthesized via a Mannich reaction between a sec. amine (e.g. piperidine, pyrrolidine, morpholine, or dibenzylamine,) and 5-cyano or 5-azidomethyl-8-hydroxyquinoline, which were respectively obtained by nucleophilic displacement of 5-chloromethyl-8-hydroxyquinoline by cyanide or azide anions. In all cases, a single product was isolated in medium to fair yield and characterized on the basis of 1H and 13C-NMR, MS and IR spectrometric data. The X-ray structure of the product obtained from 5-cyanomethyl-8-hydroxyquinoline and piperidine is also reported.
