1049705-20-5Relevant academic research and scientific papers
A synthetic and spectroscopic investigation of the asymmetric α-lithiation-trapping of six-membered N-Boc heterocycles using Alexakis diamines
Firth, James D.,Gelardi, Giacomo,Rayner, Peter J.,Stead, Darren,O’Brien, Peter
, p. 1288 - 1303 (2019/07/31)
– The asymmetric lithiation-trapping of six-membered N-Boc heterocycles using s-BuLi and two different Alexakis diamines is reported. These readily available ligands outperform the current ‘best-in-class’ sparteine-type diamines in the lithiation and benz
An enantioselective synthetic route to cis-2,4-disubstituted and 2,4-bridged piperidines
Amat, Mercedes,Perez, Maria,Minaglia, Annamaria T.,Bosch, Joan
, p. 6920 - 6923 (2008/12/22)
(Chemical Equation Presented) A synthetic route to enantiopure cis-2,4-disubstituted and 2,4-bridged piperidines is reported, the key step being a stereoselective conjugate addition of an organocuprate to a phenylglycinol-derived unsaturated lactam bearing a substituent at the 8a-position.
