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Usage

Uses

Used in Pharmaceutical Industry:
(3R)-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals, specifically for the development of antimalarial and antipsychotic drugs. Its tetrahydroisoquinoline ring and carboxylic acid group endow it with biological activity and chemical reactivity, making it a valuable building block for creating new drug compounds with therapeutic potential.

Upstream product

• 124455-25-0 (R)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3,4-dihydro-2H-isoquinolin-1-one 
• 97936-10-2 Beak's reagent 
• 124455-22-7 (R)-3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-(4-methoxy-benzyl)-3,4-dihydro-2H-isoquinolin-1-one 
• 124455-26-1 (R)-3-((S)-1,2-Dihydroxy-ethyl)-3,4-dihydro-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

Diastereoselective Addition of Lithiated N,N-Diethyl-o-Toluamide to Chiral Isopropylidene Glyceraldehyde Imines. Asymmetric Synthesis of 3-Substituted 3,4-Dihydro-1(2H)-isoquinolones

The lithio derivative of N,N-diethyl-o-toluamide adds regiospecifically to (R)- and (S)-glyceraldehyde acetonide p-methoxybenzyl imines to afford the Cram-chelation controlled products (3S,1'R)-(3) and (3R,1')-(3), respectively.