1049772-79-3

Usage

Physical state

Yellow solid.

Chemical family

Pyrazole.

Uses

Commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.

Biological activities

Studied for its potential as an antiviral and antitumor agent.

Chemical properties

Strong electron-withdrawing properties due to the presence of the trifluoromethyl group, making it valuable in various chemical reactions and applications.

Upstream product

• 339011-85-7 2-((dimethylamino)methylene)-4,4,4-trifluoro-3-oxobutyronitrile 
• 60-34-4 methylhydrazine 
• 1037593-86-4 3-cyclohexyl(methyl)amino-2-trifluoroacetylacrylonitrile 
• 1037593-87-5 3-morpholino-2-trifluoroacetylacrylonitrile 
• 1037593-85-3 3-pyrrolidino-2-trifluoroacetylacrylonitrile 

Downstream Products

• 113100-53-1 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Halogen-containing pyrazoleformonitrile derivative synthesis method

The present invention discloses a halogen-containing pyrazoleformonitrile derivative synthesis method, which comprises that a dialkylacrylonitrile represented by a formula (1) and a carboxylic acid represented by a formula (2) are subjected to an acylation reaction in the presence of a halogenating agent and an organic alkali to obtain 2-acyl-1-aminoacrylonitrile represented by a formula (3), and the 2-acyl-1-aminoacrylonitrile represented by the formula (3) and a substituted hydrazine represented by a formula (4) are subjected to a cyclization reaction under an alkali condition to obtain the pyrazoleformonitrile derivative represented by a formula (5). According to the present invention, with the method, the less coloring 2-acyl-1-aminoacrylonitrile can be synthesized in the high yield manner and the less coloring 1,3-disubstituted pyrazole-4-formonitrile can be synthesized in the high yield and the selectivity manner, and the 1,5-disubstituted pyrazole-4-formonitrile isomer in the product is significantly reduced. The formulas (1)-(5) are defined in the specification.

FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME, AND FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE OBTAINED BY USING THE FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME

The present invention provides a fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same, and a fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same. A fluorine-containing acyacrylonitrile derivative prepared from a fluoroacyl derivative and an aminoacrylonitrile derivative, is reacted with a hydrazine derivative to produce a fluorine-containing pyrazolecarbonitrile derivative represented by Formula (1). In Formula (1), Rf represents an alkyl group having 1 to 6 carbon atoms and substituted with at least one fluorine atom; R1 represents an alkyl group having 1 to 6 carbon atoms and R2 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like. The fluorine-containing pyrazolecarbonitrile derivative represented by Formula (1) is reacted with water to produce a fluorine-containing pyrazolecarboxylic acid derivative.