1049772-96-4

Upstream product

• 1037593-85-3 3-pyrrolidino-2-trifluoroacetylacrylonitrile 
• 60-34-4 methylhydrazine 
• 1037593-87-5 3-morpholino-2-trifluoroacetylacrylonitrile 
• 1037593-86-4 3-cyclohexyl(methyl)amino-2-trifluoroacetylacrylonitrile 
• 339011-85-7 2-((dimethylamino)methylene)-4,4,4-trifluoro-3-oxobutyronitrile 

Relevant academic research and scientific papers

Halogen-containing pyrazoleformonitrile derivative synthesis method

The present invention discloses a halogen-containing pyrazoleformonitrile derivative synthesis method, which comprises that a dialkylacrylonitrile represented by a formula (1) and a carboxylic acid represented by a formula (2) are subjected to an acylation reaction in the presence of a halogenating agent and an organic alkali to obtain 2-acyl-1-aminoacrylonitrile represented by a formula (3), and the 2-acyl-1-aminoacrylonitrile represented by the formula (3) and a substituted hydrazine represented by a formula (4) are subjected to a cyclization reaction under an alkali condition to obtain the pyrazoleformonitrile derivative represented by a formula (5). According to the present invention, with the method, the less coloring 2-acyl-1-aminoacrylonitrile can be synthesized in the high yield manner and the less coloring 1,3-disubstituted pyrazole-4-formonitrile can be synthesized in the high yield and the selectivity manner, and the 1,5-disubstituted pyrazole-4-formonitrile isomer in the product is significantly reduced. The formulas (1)-(5) are defined in the specification.

FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME, AND FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE OBTAINED BY USING THE FLUORINE-CONTAINING PYRAZOLECARBONITRILE DERIVATIVE AND METHOD FOR PRODUCING THE SAME

The present invention provides a fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same, and a fluorine-containing pyrazolecarboxylic acid derivative obtained by using the fluorine-containing pyrazolecarbonitrile derivative and a method for producing the same. A fluorine-containing acyacrylonitrile derivative prepared from a fluoroacyl derivative and an aminoacrylonitrile derivative, is reacted with a hydrazine derivative to produce a fluorine-containing pyrazolecarbonitrile derivative represented by Formula (1). In Formula (1), Rf represents an alkyl group having 1 to 6 carbon atoms and substituted with at least one fluorine atom; R1 represents an alkyl group having 1 to 6 carbon atoms and R2 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like. The fluorine-containing pyrazolecarbonitrile derivative represented by Formula (1) is reacted with water to produce a fluorine-containing pyrazolecarboxylic acid derivative.