1049798-99-3Relevant academic research and scientific papers
Synthesis, potent anti-staphylococcal activity and QSARs of some novel 2-anilinobenzazoles
Oezden, Seckin,Atabey, Dilek,Yildiz, Sulhiye,Goeker, Hakan
, p. 1390 - 1402 (2008/09/21)
Synthesis and anti-staphylococcal activity of a number of substituted 2-anilinobenzimidazoles, benzothiazoles and benzoxazoles are reported. The anti-staphylococcal activities were evaluated in standard in vitro MIC assay method. While anilinobenzimidazole derivatives 11-45 showed very potent anti-staphylococcal activities (greatest activity with an MIC value of 0.095 μg/mL), none of the 2-anilinobenzothiazoles and benzoxazole derivatives exhibited inhibitory activity. QSAR analysis of the anilinobenzimidazoles was studied on the relationship between the anti-staphylococcal activity (MIC in μg/ml) and extrapolated log kw values.
