1049809-33-7Relevant academic research and scientific papers
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: Optimization of cellular potency
Ameriks, Michael K.,Cai, Hui,Edwards, James P.,Gebauer, Damara,Gleason, Elizabeth,Gu, Yin,Karlsson, Lars,Nguyen, Steven,Sun, Siquan,Thurmond, Robin L.,Zhu, Jian
scheme or table, p. 6135 - 6139 (2010/06/16)
Basic lipophilic substituents dramatically improved the cellular potency of a previously disclosed series of pyrazole-based arylalkyne cathepsin S inhibitors. The incorporation of substituted benzylamines in the para position of the arylalkyne maintained
CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S
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Page/Page column 51, (2008/12/08)
Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
