1049817-69-7

Basic information

• Product Name: 3-{4-Chloro-3-[(4-{[(pyridin-3-ylmethyl)amino]carbonyl}phenyl)ethynyl]phenyl}-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide
• CAS NO: 1049817-69-7
• Molecular Weight: 654.236
• Mol File: 1049817-69-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{4-Chloro-3-[(4-{[(pyridin-3-ylmethyl)amino]carbonyl}phenyl)ethynyl]phenyl}-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{4-Chloro-3-[(4-{[(pyridin-3-ylmethyl)amino]carbonyl}phenyl)ethynyl]phenyl}-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide(1049817-69-7)
• EPA Substance Registry System: 3-{4-Chloro-3-[(4-{[(pyridin-3-ylmethyl)amino]carbonyl}phenyl)ethynyl]phenyl}-1-(3-thiomorpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide(1049817-69-7)

Safety Data

• Hazardous Substances Data: 1049817-69-7(Hazardous Substances Data)

Upstream product

• 102297-41-6 3-<amino>methyl>pyridine 
• 144693-65-2 4-ethynylbenzoic acid sodium salt 
• 1422264-39-8 C₂₀H₂₅ClIN₅OS 

Relevant articles and documents

Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region

Novel classes of tetrahydropyrido-pyrazole thioether amines and arylalkynes that display potency against human Cathepsin S have been previously reported. Here, key pharmacophoric elements of these two classes are merged, and SAR investigations of the P4 region are described, in conjunction with re-optimization of the P5 and P1/P1′/P3 regions. Identification of meta-substituted arylalkynes with good potency and improved solubility is described.