104990-30-9Relevant academic research and scientific papers
Preparation method of two high-purity clevidipine butyrate impurities
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Paragraph 0009; 0021-0022, (2020/07/28)
The invention relates to a preparation method of two clevidipine butyrate impurities of 4-(2, 4-dichlorophenyl)-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridine dicarboxylic acid methyl ester butyryloxy methyl ester (I) and 4-(3, 4-dichlorophenyl)-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridine dicarboxylic acid methyl ester butyryloxy methyl ester (II). Through preparation of the clevidipine butyrate impurities, an impurity reference substance is provided for quality research of clevidipine butyrate. I:R1=Cl, R2=H; II:R1=H, R2=Cl.
Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes
Brigance, Robert P.,Meng, Wei,Fura, Aberra,Harrity, Thomas,Wang, Aiying,Zahler, Robert,Kirby, Mark S.,Hamann, Lawrence G.
scheme or table, p. 4395 - 4398 (2010/09/18)
Several pyrazolo-, triazolo-, and imidazolopyrimidines were synthesized and evaluated as inhibitors of DPP4. Of these three classes of compounds, the imidazolopyrimidines displayed the greatest potency and demonstrated excellent selectivity over the other
