1050-48-2 Usage
Uses
Used in Pharmaceutical Industry:
Benzilonium bromide is used as an anticholinergic drug for its ability to block the action of acetylcholine, a neurotransmitter, in the nervous system. This property makes it useful in treating conditions that involve overactivity of the parasympathetic nervous system, such as certain gastrointestinal disorders.
Used in Chemical Synthesis:
In the chemical industry, benzilonium bromide can be used as an intermediate in the synthesis of various organic compounds. Its light brown solid form and specific chemical properties make it a valuable component in the creation of a range of products.
Used in Research and Development:
Due to its unique chemical properties, benzilonium bromide is also utilized in research and development for the study of anticholinergic effects and potential applications in medicine and other fields. This can lead to the discovery of new drugs or therapies that can benefit human health.
Originator
Pharm Chemical
Manufacturing Process
A mixture containing of 23 g of 1-ethyl-3-hydroxypyrrolidine, 51.2 g of
ethylbenzilate and 1.50 ml of benzene is subjected to azeotropic distillation to
remove traces of water and then 250 mg of metallic sodium added to the
residual solution. The mixture heated under reflux for about 8 hours while
slowly drawing off the benzene-alcohol azeotrope formed. The reaction
mixture is cooled, treated with 1 ml of acetic acid and washed with water. The
benzene is removed by distillation and the residue distilled in vacuo to obtain
the desired 1-ethyl-3-pyrrolidinyl benzilate as a viscous oil; yield 44 g,
68.1%; b.p. 164-170°C at 0.2 mm.
If desired, this same product can be prepared by adding 8 g of 1-ethyl-3-
hydroxypyrrolidine in about 40 ml of dry methylene dichloride to 18.4 g of
diphenylchloroacetyl chloride in about 40 ml of boiling methylene dichloride
and refluxing the mixture for 1 hour. The solvent is evaporated and the
residue heated on a steam bath with 200 ml of water for 5 min and then allowed to stand at room temperature for 2 days. The mixture is treated with
potassium carbonate, extracted with benzene and the benzene distilled from
the extract to obtain crude l-ethyl-3-pyrrolidinyl benzilate. Distillation in vacuo
yields the pure l-ethyl-3-pyrrolidinyl benzilate; yield 8 g (31%); b.p. 197°C at
2 mm.
22 g of 1-ethyl-3-pyrrolidinyl benzilate prepared by either of the above
methods is mixed with 32 g of ethyl bromide in 100 ml of isopropanol and
refluxed for 1 hour to give 23 g of 1,1-diethyl-3-pyrrolidinium bromide
benzilate, m.p.196-197°C.
Therapeutic Function
Anticholinergic
Check Digit Verification of cas no
The CAS Registry Mumber 1050-48-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,5 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1050-48:
(6*1)+(5*0)+(4*5)+(3*0)+(2*4)+(1*8)=42
42 % 10 = 2
So 1050-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H28NO3.BrH/c1-3-23(4-2)16-15-20(17-23)26-21(24)22(25,18-11-7-5-8-12-18)19-13-9-6-10-14-19;/h5-14,20,25H,3-4,15-17H2,1-2H3;1H/q+1;/p-1
