105006-99-3Relevant academic research and scientific papers
Intracellular Ruthenium-Promoted (2+2+2) Cycloadditions
Miguel-ávila, Joan,Tomás-Gamasa, María,Mascare?as, José L.
, p. 17628 - 17633 (2020/08/14)
Metal-mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either uncaging or redox processes. Demonstrated here for the first time is the viability of performing multicomponent alkyne cycloaromatizations inside live mammalian cells using ruthenium catalysts. Both fully intramolecular and intermolecular cycloadditions of diynes with alkynes are feasible, the latter providing an intracellular synthesis of appealing anthraquinones. The power of the approach is further demonstrated by generating anthraquinone AIEgens (AIE=aggregation induced emission) that otherwise do not go inside cells, and by modifying the intracellular distribution of the products by simply varying the type of ruthenium complex.
Allenl azide cycloaddtion chemistry. Photochemical initiation and cul mediation leads to improved regioselectivity
Feldman II, Ken S.,Hester, D. Keith,Lpez, Carlos Silva,Faza, Olalla Nieto
supporting information; experimental part, p. 1665 - 1668 (2009/04/10)
Irradiation of 2-(3-alkenyl)allenylphenyl azides in the presence of excess Cul furnished functionalized 2,3-cyclopentenylindoles in good yield with only trace amounts of competitive C-N-bonded regioisomeric products. These results represent a significant departure from the modest to-nonexistent regioselectivity that attended thermal cyclization of these allenyl azide substrates.
