105016-65-7

Usage

Uses

Used in Pharmaceutical Industry:
Etoposide 3',4'-Quinone is used as a precursor for the semiquinone free radical of Etoposide, which is crucial for its pharmaceutical applications. Its ability to inactivate φX174 DNA makes it a valuable compound in the development of drugs targeting specific genetic material.
Additionally, Etoposide 3',4'-Quinone may be used in the development of anticancer drugs, as its precursor role in the formation of the semiquinone free radical of Etoposide could potentially contribute to the inhibition of tumor growth and progression. However, further research and development would be necessary to explore this application fully.

Upstream product

• 33419-42-0 etoposide 

Downstream Products

• 121079-15-0 (5R,5aR,8aR,9S)-5-(3-Amino-4-hydroxy-5-methoxy-phenyl)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant academic research and scientific papers

Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry

The anticancer drug etoposide is associated with leukemias with MLL gene translocations and other translocations as a treatment complication. The genotype of cytochrome P450 3A4 (CYP3A4), which converts etoposide to its catechol metabolite, influences the

Mechanism of electrooxidation of substituted phenols in aqueous solutions: some podophyllotoxin derivates as models

Etoposide (1) and teniposide (2) proved to be suitable models for oxidation of phenols, because radicals formed by the one-electron oxidation of their phenolates do not dimerize.Mechanism (1)-(6) indicates in which pH range the oxidation occurs in a singl

Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells

Etoposide is a widely used antineoplastic agent that has provided great success in the treatment of childhood leukemias and other malignancies. Unfortunately, its use is associated with the increased risk of development of secondary acute myelogenous leuk

The ortho-quinone metabolite of the anticancer drug etoposide (VP-16) is a potent inhibitor of the topoisomerase II/DNA cleavable complex

Epipodophyllotoxin derivatives, such as etoposide (VP-16), constitute an important class of anticancer agents, the major cytotoxic effects of which are associated with trapping of the topoisomerase II/DNA cleavable complex and formation of protein-DNA cro