1050190-70-9Relevant academic research and scientific papers
Novel bradykinin-1 antagonists containing a (1,2,3,4-tetrahydro-isoquinolin-1-yl)acetic acid scaffold
Huszar, Jozsef,Timar, Zoltan,Szalai, Krisztina Katalin,Keseru, Gyoergy,Fueloep, Ferenc,Penke, Botond
, p. 1552 - 1558 (2008)
A novel B1 antagonist core was utilized and the effects of modification of its amide side chain on the biological activity were tested. The imino functional group of isoquinolin-1-ylacetic acid and its 6,7-dimethoxy variant was sulfonylated (4-toluenesulfonyl), while the acetyl side chain was converted to amides. Three of the synthesized compounds exhibited significant activity at the recombinant human B1 receptors in binding tests and also in a functional assay.
