1050207-89-0

Basic information

• Product Name: 4-(4-methyl-1-piperazinyl)-2-(methylthio)-7-(phenylmethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-5-carboxylic acid methyl ester
• CAS NO: 1050207-89-0
• Molecular Weight: 483.659
• Mol File: 1050207-89-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(4-methyl-1-piperazinyl)-2-(methylthio)-7-(phenylmethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-5-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methyl-1-piperazinyl)-2-(methylthio)-7-(phenylmethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-5-carboxylic acid methyl ester(1050207-89-0)
• EPA Substance Registry System: 4-(4-methyl-1-piperazinyl)-2-(methylthio)-7-(phenylmethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-5-carboxylic acid methyl ester(1050207-89-0)

Safety Data

• Hazardous Substances Data: 1050207-89-0(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1050207-73-2 4-chloro-2-(methylthio)-7-(phenylmethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-5-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and receptor binding of new thieno[2,3-d]-pyrimidines as selective ligands of 5-HT3 receptors

With the aim to develop new potent and selective ligands of 5-HT 3-type serotonin receptors and to acquire more information on their structure-affinity relationships, new thieno[2,3-d]pyrimidine derivatives 32-39 were synthesized and their binding to 5-HT3 versus 5-HT4 receptors was studied. Some of these new compounds exhibit good affinity for cortical 5-HT3 receptors, but not for 5-HT4 receptors. Among these derivatives, 6-ethyl-4-(4-methyl-1-piperazinyl)-2-(methylthio)- thieno[2,3-d]pyrimidine 32 is the most potent ligand (Ki = 67 nM); it behaves as a competitive antagonist of the 5-HT3 receptor function in the guinea pig colon. Its binding interactions with 5-HT3A receptors were analysed by using receptor modelling and comparative docking.