105024-96-2

Basic information

• Product Name: 1-benzyl-2-hydroxyquinolin-4(1H)-one
• CAS NO: 105024-96-2
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.2799
• Mol File: 105024-96-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 415.7°C at 760 mmHg
• Flash Point: 205.2°C
• Density: 1.319g/cm³
• Vapor Pressure: 1.18E-07mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 1-benzyl-2-hydroxyquinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-2-hydroxyquinolin-4(1H)-one(105024-96-2)
• EPA Substance Registry System: 1-benzyl-2-hydroxyquinolin-4(1H)-one(105024-96-2)

Safety Data

• Hazardous Substances Data: 105024-96-2(Hazardous Substances Data)

Usage

Type of compound

Synthetic chemical compound

Potential medicinal properties

Inhibits the growth of cancer cells

Other properties

Antioxidant and anti-inflammatory

Research status

Preclinical studies; ongoing research for potential applications in medicine

Structure

Contains a benzyl group attached to a hydroxyquinoline ring

Unique properties

Chemical and biological properties due to the presence of the benzyl and hydroxyquinoline groups

Upstream product

• 758640-21-0 N-Benzylaniline 
• 118-48-9 isatoic anhydride 
• 130058-54-7 ethyl 4-hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinecarboxylate 
• 20877-86-5 N-phenyl isatoic anhydride 
• 141-82-2 malonic acid 
• 1373442-14-8 ethyl 3-(benzyl (phenyl)amino)-3-oxopropanoate 

Downstream Products

• 1115195-55-5 C₂₂H₂₁NO₂ 
• 686271-54-5 C₆H₄ClNO₆S₂ 

Relevant articles and documents

Efficient synthesis of bicyclo[3.3.1]nonane systems via tandem 1,3-dinucleophilic addition of 4-hydroxy-2-quinolinones to quinolinium salts

The synthesis of bicyclo[3.3.1]nonane systems is reported. The synthesis is based on the tandem 1,3-dinucleophilic addition of 4-hydroxy-2-quinolinone to quinolinium salts.

Anti-infective agents

Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Acyl and alkoxy substituted quinolines

Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are are represented by compounds of Formula 1.0: STR1 and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 and methods of treating a viral infection using compounds represented by Formula 1.0 are disclosed. Also disclosed are compounds useful as antihypertensive agents and methods of treating hypertension using such compounds. The antihypertensive agents are compounds represented by Formula 1.0 wherein R4 is selected from the group consisting of alkyl and aminoalkyl. Preferably R1 is H.