10503-10-3 Usage
Uses
Used in Pharmaceutical Industry:
4-Chloro-3-indazole carboxylic acid is used as a key intermediate in the synthesis of indazolyldiazepine serotonin antagonists. These antagonists are important in the development of medications targeting various central nervous system disorders, such as anxiety, depression, and obsessive-compulsive disorder. The compound's structural properties allow for the creation of selective and potent serotonin receptor modulators, which can help in the treatment of these conditions.
Used in Agrochemical Industry:
4-Chloro-3-indazole carboxylic acid is also utilized in the preparation of indazole-3-carboxamides, which are known to possess herbicidal properties. These compounds are used in the development of herbicides to control the growth of unwanted plants in agricultural fields. The herbicidal activity of indazole-3-carboxamides is attributed to their ability to inhibit plant growth by targeting specific enzymes or receptors in the plant's metabolic pathways. This application helps improve crop yield and quality by reducing competition for resources and minimizing damage caused by weeds.
Check Digit Verification of cas no
The CAS Registry Mumber 10503-10-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,0 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10503-10:
(7*1)+(6*0)+(5*5)+(4*0)+(3*3)+(2*1)+(1*0)=43
43 % 10 = 3
So 10503-10-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClN2O2/c9-4-2-1-3-5-6(4)7(8(12)13)11-10-5/h1-3H,(H,10,11)(H,12,13)
10503-10-3Relevant academic research and scientific papers
Synthetic method of 4-fluoroindazole 3-carbonitrile or derivative thereof
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Paragraph 0042; 0044-0046, (2020/12/10)
The invention is applicable to the technical field of chemical synthesis, and provides a synthesis method of 4-fluoroindazole 3-carbonitrile or derivatives thereof, which comprises the following steps: reacting 2-fluoro-6-nitrophenylacetaldehyde, ethanol, sodium bicarbonate, hydroxylamine hydrochloride and water to obtain 2-fluoro-6-nitrophenylethyloxime; reacting 2-fluoro-6-nitroacetoxime with acetic anhydride to obtain 2-fluoro-6-nitrophenylacetonitrile; reacting 2-fluoro-6-nitrophenylacetonitrile, tetrahydrofuran, methanol, water, ammonium chloride and iron powder, and reacting with glacialacetic acid and acetic anhydride to obtain 2-acetylamino-6-fluorophenylacetonitrile; reacting 2-acetylamino-6-fluorophenylacetonitrile, glacial acetic acid, acetic anhydride and isoamyl nitrite, andreacting with ethanol and sodium hydroxide to obtain the 4-fluoroindazole 3-carbonitrile. The synthesis method provided by the invention is mild in reaction condition and easy to operate, and the adopted raw materials are conventional and harmless.
