10503-10-3

Basic information

• Product Name: 4-CHLORO-3-INDAZOLE CARBOXYLIC ACID
• Synonyms: 4-CHLORO-3-INDAZOLE CARBOXYLIC ACID;4-CHLOROINDAZOLECARBOXYLIC ACID;1H-Indazole-3-carboxylicacid,4-chloro-;4-chloro-1H-indazol-3-carboxylic acid;4-Chloro-3-indazole carbocylic acid
• CAS NO: 10503-10-3
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.59
• Mol File: 10503-10-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 472.1 °C at 760 mmHg
• Flash Point: 239.3 °C
• Appearance: /
• Density: 1.644 g/cm³
• Vapor Pressure: 1.02E-09mmHg at 25°C
• Refractive Index: 1.744
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-3-INDAZOLE CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-INDAZOLE CARBOXYLIC ACID(10503-10-3)
• EPA Substance Registry System: 4-CHLORO-3-INDAZOLE CARBOXYLIC ACID(10503-10-3)

Safety Data

• Hazardous Substances Data: 10503-10-3(Hazardous Substances Data)

Usage

Uses

4-Chloro-1H-indazole-3-carboxylic Acid may be useful in the preparation of indazolyldiazepine serotonin antagonist. It may also be useful in the preparation of indazole-3-carboxamides as herbicides.

InChI:InChI=1/C8H5ClN2O2/c9-4-2-1-3-5-6(4)7(8(12)13)11-10-5/h1-3H,(H,10,11)(H,12,13)

Relevant articles and documents

Synthetic method of 4-fluoroindazole 3-carbonitrile or derivative thereof

The invention is applicable to the technical field of chemical synthesis, and provides a synthesis method of 4-fluoroindazole 3-carbonitrile or derivatives thereof, which comprises the following steps: reacting 2-fluoro-6-nitrophenylacetaldehyde, ethanol, sodium bicarbonate, hydroxylamine hydrochloride and water to obtain 2-fluoro-6-nitrophenylethyloxime; reacting 2-fluoro-6-nitroacetoxime with acetic anhydride to obtain 2-fluoro-6-nitrophenylacetonitrile; reacting 2-fluoro-6-nitrophenylacetonitrile, tetrahydrofuran, methanol, water, ammonium chloride and iron powder, and reacting with glacialacetic acid and acetic anhydride to obtain 2-acetylamino-6-fluorophenylacetonitrile; reacting 2-acetylamino-6-fluorophenylacetonitrile, glacial acetic acid, acetic anhydride and isoamyl nitrite, andreacting with ethanol and sodium hydroxide to obtain the 4-fluoroindazole 3-carbonitrile. The synthesis method provided by the invention is mild in reaction condition and easy to operate, and the adopted raw materials are conventional and harmless.