1050392-29-4

Basic information

• Product Name: 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine
• Synonyms: 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine;3-(4-Methoxyphenyl)-4-methyl-5-isothiazolamine;5-IsothiazolaMine, 3-(4-Methoxyphenyl)-4-Methyl-
• CAS NO: 1050392-29-4
• Molecular Formula: C₁₁H₁₂N₂OS
• Molecular Weight: 220.29078
• Mol File: 1050392-29-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 294.6 °C at 760 mmHg
• Flash Point: 132 °C
• Appearance: /
• Density: 1.223
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine(1050392-29-4)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine(1050392-29-4)

Safety Data

• Hazardous Substances Data: 1050392-29-4(Hazardous Substances Data)

Usage

General Description

3-(4-methoxyphenyl)-4-methylisothiazol-5-amine is a chemical compound that belongs to the isothiazolone class. It is commonly used as a preservative in various personal care products, such as shampoos, conditioners, and moisturizers. 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine is known for its antimicrobial properties, which help prevent the growth of bacteria, fungi, and other microorganisms in these products, thereby extending their shelf life. However, it is important to note that 3-(4-methoxyphenyl)-4-methylisothiazol-5-amine can also be a skin irritant and allergen for some individuals, and therefore should be used with caution, especially in products that come in direct contact with the skin.

InChI:InChI=1S/C11H12N2OS/c1-7-10(13-15-11(7)12)8-3-5-9(14-2)6-4-8/h3-6H,12H2,1-2H3

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 1050392-22-7 C₁₁H₁₄N₂OS 
• 1050392-15-8 C₁₁H₁₂N₂O 

Downstream Products

• 1050393-23-1 (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2-methylcyclopropanecarboxamide 
• 1050392-36-3 4-(5-amino-4-methylisothiazol-3-yl)phenol 
• 1050392-40-9 (R,R)-N-[3-(4-hydroxyphenyl)-4-methylisothiazol-5-yl]-2-methylcyclopropanecarboxamide 

Relevant articles and documents

3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity

The disclosed 3-phenyl-5-isothiazole carboxamides are potent allosteric antagonists of mGluR1 with generally good selectivity relative to the related group 1 receptor mGluR5. Pharmacokinetic properties of a member of this series (1R,2R)-N-(3-(4-methoxyphenyl)-4-methylisothiazol-5-yl)-2- methylcyclopropanecarboxamide (14) are good, showing acceptable plasma and brain exposure after oral dosing. Oral administration of isothiazole 14 gave robust activity in the formalin model of persistent pain which correlated with CNS receptor occupancy.