1050424-03-7

Basic information

• Product Name: 4-BORONO-2-(TRIFLUOROMETHYL)BENZOIC ACID
• Synonyms: 4-BORONO-2-(TRIFLUOROMETHYL)BENZOIC ACID;4-carboxy-3-trifluoromethylphenylboronic acid;4-Borono-2-(trifluoromethyl)
• CAS NO: 1050424-03-7
• Molecular Formula: C₈H₆BF₃O₄
• Molecular Weight: 233.9370496
• Mol File: 1050424-03-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 253-254 °C (decomp)
• Boiling Point: 382.9±52.0 °C(Predicted)
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Methanol (Slightly)
• PKA: 3.11±0.36(Predicted)
• CAS DataBase Reference: 4-BORONO-2-(TRIFLUOROMETHYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BORONO-2-(TRIFLUOROMETHYL)BENZOIC ACID(1050424-03-7)
• EPA Substance Registry System: 4-BORONO-2-(TRIFLUOROMETHYL)BENZOIC ACID(1050424-03-7)

Safety Data

• Hazardous Substances Data: 1050424-03-7(Hazardous Substances Data)

Usage

Uses

4-Borono-2-(trifluoromethyl)benzoic Acid is a reagent used in the preparation of Novel 3H-?[1,?2,?3]?triazolo[4,?5-?c]?pyridine derivatives which are potential GPR119 agonists with antidiabetic properties.

Upstream product

• 124-38-9 carbon dioxide 
• 364-11-4 1-bromo-4-iodo-2-(trifluoromethyl)benzene 

Relevant articles and documents

One-pot generation of lithium (lithiophenyl)trialkoxyborates from substituted dihalobenzenes (Hal = Br, I) and their derivatization with electrophiles

The simple one-pot approach to synthetically useful phenyltrialkoxyborates bearing lithium at the phenyl ring has been developed starting with 1,3- and 1,4-diiodobenzene, as well as several activated dibromobenzenes and bromoiodobenzenes. The general sequence of transformations involves halogen-lithium exchange by using nBuLi and subsequent boronation with a trialkylborate. The resulting lithium (halophenyl) trialkoxyborates were then subjected to halogen-lithium exchange in situ with a second equivalent of nBuLi to give dianionic lithium (lithiophenyl)trialkoxyborates. Treatment with selected electrophiles afforded substituted arylboronic acids and/or their pinacol esters as final products in moderate-to-good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.