1050500-41-8

Basic information

• Product Name: PEG13-Tos
• Synonyms: PEG13-Tos;PEG15-Tos;Tos-PEG12-OH
• CAS NO: 1050500-41-8
• Molecular Formula: C31H56O15S
• Molecular Weight: 700.83234
• Mol File: 1050500-41-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PEG13-Tos(CAS DataBase Reference)
• NIST Chemistry Reference: PEG13-Tos(1050500-41-8)
• EPA Substance Registry System: PEG13-Tos(1050500-41-8)

Safety Data

• Hazardous Substances Data: 1050500-41-8(Hazardous Substances Data)

Usage

Description

PEG13-Tos is a PEG linker containing a hydroxyl group and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

PEG13-tos is a cross linker in the synthesis antibody-drug conjugates.

Upstream product

• 6790-09-6 dodecaethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1456708-45-4 3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate) 

Relevant articles and documents

Organometallic Gold(III) Reagents for Cysteine Arylation

An efficient method for chemoselective cysteine arylation of unprotected peptides and proteins using Au(III) organometallic complexes is reported. The bioconjugation reactions proceed rapidly (5 min) at ambient temperature in various buffers and within a wide pH range (0.5-14). This approach provides access to a diverse array of S-aryl bioconjugates including fluorescent dye, complex drug molecule, affinity label, poly(ethylene glycol) tags, and a stapled peptide. A library of Au(III) arylation reagents can be prepared as air-stable, crystalline solids in one step from commercial reagents. The selective and efficient arylation procedures presented in this work broaden the synthetic scope of cysteine bioconjugation and serve as promising routes for the modification of complex biomolecules.

CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO

In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

The intermediate body of polyethylene glycol derivatives and manufacturing method

PROBLEM TO BE SOLVED: To provide a simple method for producing a production intermediate of a polyethylene glycol derivative, and further to provide a large number of compounds useful as effective components of an antitumor agent by virtue of the method. SOLUTION: A polyethylene glycol monoether compound represented by formula (1) (in the formula, R represents a hydrocarbon group that may contain a substituent, and n represents a positive integer) or its salt is produced by using a compound resulting from esterifying one hydroxy group alone of a polyethylene glycol compound with a p-toluenesulfonyl group. COPYRIGHT: (C)2010,JPOandINPIT