1050654-48-2Relevant academic research and scientific papers
Organocatalytic α-amination-allylation-RCM strategy: enantioselective synthesis of cyclic hydrazines
Lim, Aram,Choi, Jung Hoon,Tae, Jinsung
, p. 4882 - 4885 (2008/12/20)
A highly enantioselective method for the synthesis of cyclic hydrazines by using organocatalytic α-amination-allylation-RCM strategy is described. Proline-catalyzed α-amination of aldehydes followed by indium-mediated one-pot allylation of the crude α-hydrazino aldehydes produces 1,2-aminoalcohols in high enantio- and diastereoselectivities. The 1,2-aminoalcohols are further converted into cyclic hydrazines by using ring-closing metathesis (RCM) reaction.
