Cas 1050656-31-9,1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid

1050656-31-9

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Basic information

Product Name: 1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid
Synonyms: 1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid
CAS NO:1050656-31-9
Molecular Formula:
Molecular Weight: 319.283
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid(CAS DataBase Reference)
NIST Chemistry Reference: 1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid(1050656-31-9)
EPA Substance Registry System: 1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxylic acid(1050656-31-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1050656-31-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1050656-31-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,0,6,5 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1050656-31:
(9*1)+(8*0)+(7*5)+(6*0)+(5*6)+(4*5)+(3*6)+(2*3)+(1*1)=119
119 % 10 = 9
So 1050656-31-9 is a valid CAS Registry Number.

1050656-31-9Upstream product

1050656-28-4 1-(4-trifluoromethyl-benzyl)-1H-indole-7-carboxylic acid methyl ester

1050656-31-9Downstream Products

1050656-31-9Relevant academic research and scientific papers

COMPOUND FOR INHIBITING PGE2/EP4 SIGNALING TRANSDUCTION INHIBITING, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF

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, (2022/03/14)

A compound of formula (I), a preparation method therefor, a pharmaceutical composition containing a derivative thereof, and the therapeutic uses thereof, especially inhibiting PGE2/EP4 signalling transduction and the uses thereof for treating cancer, acute or chronic pain, migraine, osteoarthritis, rheumatoid arthritis, gout, bursitis, ankylosing spondylitis, primary dysmenorrhea, tumour or arteriosclerosis.

Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl) amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP 4 antagonist for treating inflammatory pain

Colucci, John,Boyd, Michael,Berthelette, Carl,Chiasson, Jean-Francois,Wang, Zhaoyin,Ducharme, Yves,Friesen, Rick,Wrona, Mark,Levesque, Jean-Francois,Denis, Danielle,Mathieu, Marie-Claude,Stocco, Rino,Therien, Alex G.,Clarke, Patsy,Rowland, Steve,Xu, Daigen,Han, Yongxin

scheme or table, p. 3760 - 3763 (2010/09/03)

The discovery of a highly potent and selective EP4 antagonist MF-766 is discussed. This N-benzyl indole derivative exhibits good pharmacokinetic profile and unprecedented in vivo potency in the rat AIA model.

PROCESS FOR MAKING INDOLE CYCLOPROPYL AMIDE DERIVATIVES

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Page/Page column 9; 11, (2010/11/05)

An efficient and economical process for synthesizing kilogram quantities of an indole cyclopropyl amide derivative of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed. The process comprises the coupling of indolecarboxylic acid der

INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

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Page/Page column 28-29, (2008/12/08)

The invention is directed to indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Ph

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