1050826-75-9

Basic information

• Product Name: [1-(2-nitro-benzyl)-piperidin-4-yl]-phenyl-methanone
• Synonyms: [1-(2-nitro-benzyl)-piperidin-4-yl]-phenyl-methanone
• CAS NO: 1050826-75-9
• Molecular Weight: 324.379
• Mol File: 1050826-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-(2-nitro-benzyl)-piperidin-4-yl]-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(2-nitro-benzyl)-piperidin-4-yl]-phenyl-methanone(1050826-75-9)
• EPA Substance Registry System: [1-(2-nitro-benzyl)-piperidin-4-yl]-phenyl-methanone(1050826-75-9)

Safety Data

• Hazardous Substances Data: 1050826-75-9(Hazardous Substances Data)

Upstream product

• 37586-22-4 4-benzoylpiperidine 
• 3958-60-9 2-nitrophenylmethyl bromide 

Downstream Products

• 1026081-45-7 [2-(4-benzoyl-piperidin-1-ylmethyl)-phenyl]-carbamic acid phenyl ester 
• 1027989-68-9 [1-(2-amino-benzyl)-piperidin-4-yl]-phenyl-methanone 

Relevant articles and documents

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists

Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils.