105123-90-8

Basic information

• Product Name: 1-(2-chloro-4-methylphenyl)piperidin-4-one
• Synonyms: 1-(2-chloro-4-methylphenyl)piperidin-4-one
• CAS NO: 105123-90-8
• Molecular Formula: C₁₂H₁₄ClNO
• Molecular Weight: 223.69866
• Mol File: 105123-90-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-chloro-4-methylphenyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloro-4-methylphenyl)piperidin-4-one(105123-90-8)
• EPA Substance Registry System: 1-(2-chloro-4-methylphenyl)piperidin-4-one(105123-90-8)

Safety Data

• Hazardous Substances Data: 105123-90-8(Hazardous Substances Data)

Usage

General Description

1-(2-chloro-4-methylphenyl)piperidin-4-one is a chemical compound with a molecular formula C12H14ClNO. It contains a piperidinone ring with a phenyl group attached at the 2-position, and a chlorine atom and a methyl group attached at the 4-position. 1-(2-chloro-4-methylphenyl)piperidin-4-one is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has been studied for its potential use in medical research, particularly in the development of new drugs for a range of medical conditions. Additionally, it may have potential applications in the field of organic chemistry as a building block for creating new compounds with specific properties.

Upstream product

• 105123-92-0 2'-O-[1-(2-Chloro-4-methylphenyl)-4-methoxypiperidin-4-yl]uridine 
• 105123-88-4 N,N-di-(2-ethoxycarbonylethyl)-p-toluidine 
• 105123-89-5 1-(4-methylphenyl)piperidin-4-one 

Downstream Products

• 115012-45-8 1-N-[(2-chloro-4-methyl)phenyl]-4,4-dimethoxypiperidine 
• 105123-97-5 C₄₁H₄₆Cl₂N₅O₁₇P 
• 105123-95-3 1-[(2R,3R,4R,5R)-3-[1-(2-Chloro-4-methyl-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 105123-92-0 2'-O-[1-(2-Chloro-4-methylphenyl)-4-methoxypiperidin-4-yl]uridine 
• 105123-91-9 1-(2-Chloro-4-methylphenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 

Relevant articles and documents

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.