1051392-63-2Relevant academic research and scientific papers
A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel β-thiophenoxy and pyridyl ethers
Huang, Kun,Ortiz-Marciales, Margarita,Stepanenko, Viatcheslav,De Jesus, Melvin,Correa, Wildeliz
, p. 6928 - 6931 (2008/12/22)
(Chemical Equation Presented) A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues with use of 10% of spiroborate ester 6 as chirality transfer agent is presented. A variety of mexiletine analogues were prepared in good yield with excellent enantioselectivities (91-97% ee) from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel β-amino ethers containing thiophenyl and pyridyl fragments.
