105149-59-5Relevant academic research and scientific papers
SUBSTITUTED 1-(2-THIENYL)CYCLOHEXYLAMINES AND RELATED COMPOUNDS AS POTENTIAL NMDA ANTAGONISTS
Sindelar, Karel,Dobrovsky, Karel,Krejci, Ivan,Polivka, Zdenek
, p. 894 - 902 (1995)
Reactions of bisulfite addition compounds prepared in situ from cyclohexanone or 3,4,5,6-tetrahydro-2H-thiopyran-3-one with potassium cyanide and corresponding amines resulted with high yields in amino nitriles type of V and VI.These compounds were subjected to reactions with 2-thienylmagnesium bromide and in the case of the amino nitriles Vc and Vf with 5-bromo-2-thienylmagnesium bromide.Only in the case of compound Vf, a by-product X was isolated in addition to the desired 1-piperidine (VIIf).Compound VIIf was used for the synthesis of the carboxylic acid XI.The compounds prepared were tested by some methods of biochemical and behavioural pharmacology.
