105159-30-6Relevant academic research and scientific papers
The First Example of a Mimic of the Overall Thymidylate Synthase Reaction
Meij, Paul F. C. van der,Chen, Tjoe B. R. A.,Hilhorst, Ellen,Waard, Eduard R. de,Pandit, Upendra K.
, p. 720 - 721 (2007/10/02)
2-Tosyl-1,2,3,13b-tetrahydroimidazophenanthridine functions as a mimic of the cofactor 5,10-methylenetetrahydrofolate in transferring both a methylene moiety and a hydride equivalent (i.e. an overall methyl group) to the C-5 position of a uracil derivative.
MODELS OF FOLATE COENZYMES 16. CHEMICAL MODELLING OF THE THYMIDYLATE SYNTHASE REACTION. EVIDENCE FOR AN "EXOCYCLIC METHYLENE INTERMEDIATE" ANALOGUE, WHICH IS REDUCIBLE TO A THYMINE DERIVATIVE, IN THE REACTION OF 6-AMINOURACILS WITH A 5,10-METHYLENETETRAHY
Meij, Paul F. C. van der,Lohmann, Ruth D.,Waard, Eduard R. De,Chen, Tjoe B. R. A.,Pandit, Upendra K.
, p. 3921 - 3930 (2007/10/02)
Reactions of 6-amino-, 6-alkylamino-, and 6-anilino-1,3-dimethyluracils (1a-1e) with 3,4-diphenyl-1-tosylimidazolidine (2), in the presence of acid, lead to the formation of products which are derived from an "exocyclic methylene intermediate" analogous t
