105174-59-2Relevant academic research and scientific papers
Synthesis and Pharmacological Evaluation of Sulfonium Analogues of Dopamine: Nonclassical Dopamine Agonists
Anderson, Karen,Kuruvilla, Alice,Uretsky, Norman,Miller, Duane D.
, p. 683 - 687 (1981)
In order to test whether the nitrogen/ammonium moiety in the dopamine molecule is required for dopaminergic activity, we have synthesized two sulfonium analogues of dopamine and tested them for biological activity in an in vivo and in vitro system.These analogues have provided a means of investigating (1) the ability of the sulfonium function to serve as a bioisostere for the dopamine amino group and (2) whether charged molecules have the ability to bind to dopamine receptors.Both sulfonium analogues, 1 and 2, as well as dopamine, when injected directly into the striatum of rats, previously lesioned unilaterally with 6-hydroxydopamine (6-OHDA), produced circling behavior.The potency of the sulfonium analogues was approximately one-tenth that of dopamine.The effects of all three compounds on circling were inhibited by the dopamine antagonist haloperidol.In addition, both sulfonium analogues inhibited the high affinity binding of radiolabeled dopamine to a crude membrane fraction prepared from the striatum.This study suggests that the nitrogen atom found in the dopamine molecule is not essential for dopaminergic activity, since the nitrogen can be replaced by a sulfonium functional group for this activity.
GRAFTABLE BIOCIDAL LINKERS AND POLYMERS AND USES THEREOF
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Paragraph 00377-00378, (2021/12/30)
Ready-to-graft polymers and compounds, surfaces grafted to same, and methods of making and using the same for controlling the growth of at least one bacteria, fungi, protozoa, or virus are disclosed.
Synthesis of Phenolic Ketones, an Ester Ketone of Guaiacol, and a Ketone of Veratrole Containing Chlorine, Bromine, or Iodine in the Side-chain
Kossmehl, Gerhard,Frohberg, Hans-Christian
, p. 50 - 64 (2007/10/02)
The ω-bromo and ω-chloro ketones 1-8, 10-14 of phenols as well as the ω-bromo ketone 9 of veratrole are synthesized according to the Friedel-Crafts acylation (FCA) using different variations and specific reaction conditions.Under these conditions hydroquinone furnishes the esters of the ω-bromo- and ω-chlorocarboxylic acids 28-31, whereas phloroglucinol does not result in defined reaction products.Guaiacol yields 16 with an ester as well as a ketone group at its aromatic nucleus.Bromination of 3',4'-dihydroxyisobutyrophenone with CuBr2 leads to 2-bromo-3',4'-dihydroxyisobutyrophenone (15).The ω-iodo ketones 17-27 of phenols and their methyl ethers have been obtained from the corresponding ω-bromo or ω-chloro ketone on treatment with NaI in acetone.
